Pruritus ↓

Pramoxine Reduces Uremic Pruritus

Wake Forest University School of Medicine conducted a randomized, double-blind, controlled comparative trial in a community hemodialysis center to evaluate the efficacy of 1% pramoxine hydrochloride lotion versus control lotion in the treatment of uremic pruritus in adult hemodialysis patients. Pramoxine 1% lotion was applied twice daily to all affected areas of pruritus for 4 weeks, resulting in a 61% decrease in itch intensity. “This safe, convenient and effective topical lotion may potentially benefit the large number of patients affected by pruritus associated with end-stage renal disease.”

J Dermatolog Treat. 2008 Sep 24:1-5.

A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients.

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The following studies evaluated a topical formulation of 1% naltrexone to treat patients with localized and generalized atopic dermatitis with severe itching, and more than 70% of patients using the 1% naltrexone cream experienced a significant reduction of pruritus.

J Cutan Med Surg. 2005 Oct;9(5):215-6

Successful treatment of refractory aquagenic pruritus with naltrexone.

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Itching Relieved with Topical Naltrexone

Pruritus is a very common and distressing skin problem. More than 70% of patients with localized and generalized atopic dermatitis with severe itching who used topical naltrexone 1% cream experienced a significant reduction of pruritus.

J Am Acad Dermatol. 2007 Jun;56(6):979-88

Treatment of pruritus with topically applied opiate receptor antagonist.

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Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. Endogenous opiates, like naltrexone, can modify pruritus by influencing the peripheral and central sensation of itch, and have been found to be successful in suppressing the perception of pruritus from many diverse origins including aquagenic pruritus.

J Cutan Med Surg. 2005 Oct;9(5):215-6

Successful treatment of refractory aquagenic pruritus with naltrexone

Click here to access the PubMed abstract of this article.